Can Your Personality Really Make You Sick?

personalityScientists have just made a groundbreaking discovery, claiming that the human immune system is directly connected with personality. Actually, the study found that the human immune system may be affected by far more things than we had ever believed. This includes not only the immune system but also, change and social behavior.

“Our findings contribute to a deeper understanding of social dysfunction in neurological disorders, such as autism and schizophrenia, and may open new avenues for therapeutic approaches,” explains Vladimir Litvak, who is the assistant professor at University of Massachusetts Medical School (UMMS).

Indeed, it is believed that the new study could have incredible implications for the treatment of neurological diseases like autism-spectrum disorder, and schizophrenia.

Along with UMMS PhD student Yang Xu, Litvak contributed to the development and employment of a novel, systems-biology approach to studying the complex dialogue between immune signalling and brain function. Litvak goes on to say, “Using this approach, we predicated an unexpected role for interferon gamma (IFN-gamma), an important cytokine secreted by T lymphocytes, in promoting social brain functions.”

With this new approach, then, Xu was able to define canonical immune signaling a new takeover .Using the new approach, Xu defined canonical immune signaling signatures as well as analyze their presence within thousands of publicly available brain transcription data-sets.

Furthermore, University of Virginia School of Medicine’s Jonathan Kipnis the study found: “The brain and the adaptive immune system were thought to be isolated from each other, and any immune activity in the brain was perceived as a sign of pathology. And now, not only are we showing that they are closely interacting, but some of our behavior traits might have evolved because of our immune response to pathogens,” said Kipnis.

On the other hand, of course, the scientists found that ceasing the blockage of the immune system molecule—which allows, again, the system to function freely within the brain—caused the mice to calm down.

In addition, study co-author Jonathan Kipnis—of the University of Virginia—comments: “It’s like a little airport in a small city suddenly becomes a major hub and so there’s a mess of traffic congestion in the air.” The results of this remarkable new study have been published online in the scientific journal Nature.

 

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