Soligenix (NASDAQ: SNGX) and Mateon Therapeutics (OTCMKTS:MATN) are both small-cap medical companies, but which is the better stock? We will compare the two companies based on the strength of their valuation, earnings, dividends, risk, profitability, analyst recommendations and institutional ownership.

Institutional & Insider Ownership

1.9% of Soligenix shares are held by institutional investors. 5.0% of Soligenix shares are held by insiders. Comparatively, 4.5% of Mateon Therapeutics shares are held by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term.

Analyst Recommendations

This is a breakdown of recent recommendations for Soligenix and Mateon Therapeutics, as reported by MarketBeat.com.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Soligenix 0 1 1 0 2.50
Mateon Therapeutics 0 1 3 0 2.75

Soligenix currently has a consensus target price of $3.85, indicating a potential upside of 95.43%. Mateon Therapeutics has a consensus target price of $1.75, indicating a potential upside of 728.21%. Given Mateon Therapeutics’ stronger consensus rating and higher possible upside, analysts plainly believe Mateon Therapeutics is more favorable than Soligenix.

Earnings and Valuation

This table compares Soligenix and Mateon Therapeutics’ gross revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Soligenix $10.45 million 1.65 -$3.24 million ($1.04) -1.89
Mateon Therapeutics N/A N/A -$13.65 million ($0.56) -0.38

Soligenix has higher revenue and earnings than Mateon Therapeutics. Soligenix is trading at a lower price-to-earnings ratio than Mateon Therapeutics, indicating that it is currently the more affordable of the two stocks.

Profitability

This table compares Soligenix and Mateon Therapeutics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Soligenix -90.93% -112.81% -71.98%
Mateon Therapeutics N/A -210.82% -175.67%

Volatility & Risk

Soligenix has a beta of 0.41, indicating that its stock price is 59% less volatile than the S&P 500. Comparatively, Mateon Therapeutics has a beta of 2.32, indicating that its stock price is 132% more volatile than the S&P 500.

Summary

Mateon Therapeutics beats Soligenix on 7 of the 13 factors compared between the two stocks.

About Soligenix

Soligenix, Inc. is a late-stage biopharmaceutical company. The Company is focused on developing and commercializing products to treat rare diseases. The Company operates through two segments: BioTherapeutics and Vaccines/BioDefense. Its BioTherapeutics segment is developing a photodynamic therapy (SGX301) utilizing topical synthetic hypericin activated with safe visible light for the treatment of cutaneous T-cell lymphoma (CTCL), formulations of oral beclomethasone 17,21-dipropionate (BDP) for the prevention/treatment of gastrointestinal (GI) disorders characterized by severe inflammation, and its innate defense regulator (IDR) technology, dusquetide (SGX942) for the treatment of oral mucositis in head and neck cancer. Its Vaccines/BioDefense business segment includes active development programs for RiVax, its ricin toxin vaccine candidate, OrbeShield, its GI acute radiation syndrome (GI ARS) therapeutic candidate, and SGX943, its melioidosis therapeutic candidate.

About Mateon Therapeutics

Mateon Therapeutics, Inc., formerly OXiGENE, Inc., is a biopharmaceutical company. The Company is focused on the development of vascular disrupting agents (VDAs) for the treatment of cancer. The Company is engaged in developing two clinical stage investigational drugs: VDAs-CA4P and OXi4503. Its lead compound is CA4P, which is also known as combretastatin A4-phosphate, fosbretabulin tromethamine, fosbretabulin and ZYBRESTAT. VDAs selectively targets the vasculature of cancer tumors and obstructs a tumor’s blood supply without disrupting the blood supply to normal tissues. VDAs are in a class of drugs called vascular targeted therapies (VTTs), which also includes anti-angiogenic agents (AAs). CA4P is a reversible tubulin binding agent that selectively targets the endothelial cells that make up the blood vessel walls in solid tumors. The Company is pursuing the development of a product candidate, OXi4503, which is a dual-mechanism VDA.

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