Icon (NASDAQ: EXEL) and Exelixis (NASDAQ:EXEL) are both mid-cap medical companies, but which is the better stock? We will compare the two companies based on the strength of their risk, institutional ownership, analyst recommendations, earnings, dividends, valuation and profitability.

Earnings and Valuation

This table compares Icon and Exelixis’ top-line revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Icon $1.76 billion 4.47 $281.48 million $5.39 26.95
Exelixis $452.48 million 10.45 $154.22 million $0.51 31.12

Icon has higher revenue and earnings than Exelixis. Icon is trading at a lower price-to-earnings ratio than Exelixis, indicating that it is currently the more affordable of the two stocks.

Profitability

This table compares Icon and Exelixis’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Icon 13.69% 26.35% 14.60%
Exelixis 48.17% 65.68% 43.81%

Analyst Ratings

This is a breakdown of recent ratings and recommmendations for Icon and Exelixis, as reported by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Icon 0 2 6 0 2.75
Exelixis 1 3 9 0 2.62

Icon currently has a consensus price target of $144.13, suggesting a potential downside of 0.79%. Exelixis has a consensus price target of $31.00, suggesting a potential upside of 95.34%. Given Exelixis’ higher probable upside, analysts clearly believe Exelixis is more favorable than Icon.

Risk and Volatility

Icon has a beta of 0.35, suggesting that its share price is 65% less volatile than the S&P 500. Comparatively, Exelixis has a beta of 1.96, suggesting that its share price is 96% more volatile than the S&P 500.

Insider & Institutional Ownership

88.0% of Icon shares are owned by institutional investors. Comparatively, 80.9% of Exelixis shares are owned by institutional investors. 44.0% of Icon shares are owned by company insiders. Comparatively, 4.8% of Exelixis shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Summary

Exelixis beats Icon on 8 of the 14 factors compared between the two stocks.

About Icon

ICON Public Limited Company, a clinical research organization, provides outsourced development services to the pharmaceutical, biotechnology, and medical device industries in Ireland, rest of Europe, the United States, and internationally. It specializes in the strategic development, management, and analysis of programs that support various stages of the clinical development process from compound selection to Phase I-IV clinical studies. The company's clinical development services include product development planning, strategic consulting, study protocol preparation, clinical pharmacology, pharmacokinetic and pharmacodynamic analysis, clinical research center, investigator site, patient recruitment, study monitoring and data collection, case report form preparation, statistical analysis, patient safety and risk-based monitoring, clinical data management, strategic analysis and data operation, regulatory consulting, and medical reporting and pharmacovigilance services. Its clinical development services also comprise interactive response technologies, electronic endpoint adjudication, medical imaging, adaptive trial design and execution, medical device and biosimilar trial, functional, strategic resourcing, sample analyses, safety testing, microbiology, custom flow cytometry, biomarker development, bioanalysis, immunoassay development, patient registries, outcomes research, health economics, market access and commercialization, drug price consulting, and healthcare and scientific communication services, as well as research trials for the U.S. government agencies, electronic transmission of test results, and electronic patient reported outcomes. The company was founded in 1990 and is headquartered in Dublin, Ireland.

About Exelixis

Exelixis, Inc., a biotechnology company, engages in the discovery, development, and commercialization of new medicines to enhance care and outcomes for people with cancer. The company's products include CABOMETYX tablets for the treatment of patients with advanced renal cell carcinoma who received prior anti-angiogenic therapy; and COMETRIQ capsules for the treatment of patients with progressive and metastatic medullary thyroid cancer. Its CABOMETYX and COMETRIQ are derived from cabozantinib, an inhibitor of multiple tyrosine kinases, including MET, AXL, RET, and VEGF receptors. It also offers COTELLIC tablets, an inhibitor of MEK in combination with vemurafenib for the treatment of patients with BRAF V600E or V600K mutation-positive advanced melanoma in the United States; and in combination with vemurafenib in other territories, including the European Union, Switzerland, Canada, Australia, and Brazil. Exelixis, Inc. has collaboration and license agreement with Ipsen Pharma SAS, Genentech, Inc., GlaxoSmithKline, Bristol-Myers Squibb Company, Sanofi, Merck, Daiichi Sankyo Company Limited, and Invenra, Inc. The company was formerly known as Exelixis Pharmaceuticals, Inc. and changed its name to Exelixis, Inc. in February 2000. Exelixis, Inc. was founded in 1994 and is headquartered in South San Francisco, California.

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