OpGen (NASDAQ:OPGN) and Castle Biosciences (NASDAQ:CSTL) are both small-cap medical companies, but which is the superior business? We will contrast the two companies based on the strength of their risk, valuation, institutional ownership, earnings, dividends, profitability and analyst recommendations.

Valuation & Earnings

This table compares OpGen and Castle Biosciences’ top-line revenue, earnings per share (EPS) and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
OpGen $2.95 million 2.91 -$13.37 million ($44.40) -0.03
Castle Biosciences N/A N/A N/A N/A N/A

Castle Biosciences has lower revenue, but higher earnings than OpGen.


This table compares OpGen and Castle Biosciences’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
OpGen -397.44% -662.90% -144.19%
Castle Biosciences N/A N/A N/A

Analyst Recommendations

This is a breakdown of recent ratings for OpGen and Castle Biosciences, as provided by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
OpGen 0 0 3 0 3.00
Castle Biosciences 0 0 5 0 3.00

OpGen presently has a consensus target price of $7.93, indicating a potential upside of 415.15%. Castle Biosciences has a consensus target price of $31.80, indicating a potential upside of 2.85%. Given OpGen’s higher possible upside, research analysts plainly believe OpGen is more favorable than Castle Biosciences.

Insider & Institutional Ownership

0.3% of OpGen shares are held by institutional investors. Comparatively, 29.0% of Castle Biosciences shares are held by institutional investors. 5.0% of OpGen shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.


Castle Biosciences beats OpGen on 5 of the 8 factors compared between the two stocks.

OpGen Company Profile

OpGen, Inc., a precision medicine company, engages in developing molecular information products and services to combat infectious diseases in the United States and internationally. The company utilizes molecular diagnostics and informatics to help combat infectious diseases. It also helps clinicians with information about life threatening infections, enhance patient outcomes, and decrease the spread of infections caused by multidrug-resistant microorganisms. The company's products include Acuitas AMR Gene Panel, a vitro diagnostic test for the detection and identification of various bacterial nucleic acids and genetic determinants of antimicrobial resistance in urine specimens or bacterial colonies isolated from urine and other body sites; and QuickFISH and PNA FISH products, which are FDA-cleared and CE-marked diagnostic test designed to detect antimicrobial- resistant pathogens. In addition, it offers Acuitas Lighthouse informatics systems, a cloud-based HIPAA compliant informatics offerings, which combine clinical lab test results with patient and hospital information, and provide analytics and insights to enable manage MDROs in the hospital and patient care environment. The company was incorporated in 2001 and is headquartered in Gaithersburg, Maryland.

Castle Biosciences Company Profile

Castle Biosciences, Inc., a commercial-stage dermatological cancer, develops and commercializes diagnostic and prognostic tests for cancers. Its lead product is DecisionDx-Melanoma, a multi-gene expression profile (GEP) test to identify stage I and II patients at high risk of metastasis based on biological information from 31 genes within their tumor tissue. The company also offers DecisionDx-UM test, a proprietary GEP test that predicts the risk of metastasis for patients with uveal melanoma, a rare eye cancer; and two late-stage proprietary products in development, which address cutaneous squamous cell carcinoma and suspicious pigmented lesions, which are indications with high clinical need in dermatological cancer. It offers test services through physicians, physician assistants, and nurse practitioners. The company was founded in 2007 and is headquartered in Friendswood, Texas.

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